Cl- absorption and HCO3- secretion are intimately associated processes vital to epithelial function, itself a key physiological activity. Until recently the transporters responsible remained obscure, but a breakthrough occurred with the discovery of the SLC26 transporters family. It is now clear that the SLC26 transporters have broad physiological functions since mutations in several members are linked to a variety of diseases. This book describes the properties of this family in detail, with contributions from the leading global researchers in the field. Complementary views from experts on other ion channels are offered in the discussions, which make fascinating reading. This family consists of at least 10 genes, each of which has several splice variants. Most members of the family are expressed in the luminal membrane of epithelial cells. Characterization of anion transport by three members has revealed that all function as Cl-/HCO3- exchangers, suggesting that SLC26 transporters are responsible for the luminal Cl-/HCO3- exchange activity. The SLC26 transporters are activated by the CF transmembrane conductance regulator and activate it in turn, leading to a model in which these molecules act together to mediate epithelial Cl- absorption and HCO3- secretion. The book includes chapters on the transport of other molecules by the SLC26 family, including oxalate in the kidney and sugars in cochlear hair cells amongst others. It also describes recent discoveries that most SLC26 transporters bind to scaffold proteins and that they all contain a conserved domain predicted to participate in protein-protein interactions. These suggest the SLC26 transporters exist in complexes with other Cl- and HCO3- transporters, and possibly other regulatory proteins. This book explores the functional role of these interactions, leading to better understanding of transepithelial fluid and electrolyte secretion and the diseases associated with it.

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Epithelial Anion Transport in Health and Disease

Ethnobotany and the Search for New Drugs

The Molecular Biology and Pathology of Elastic Tissues

Gramicidin and Related Ion Channel-Forming Peptides

Exploring Brain Functional Anatomy with Positron Tomography

Role of the Sarcoplasmic Reticulum in Smooth Muscle

T Cell Subsets in Infectious and Autoimmune Diseases

Variation in the Human Genome

Circadian Clocks and Their Adjustment

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The ultimate behind-the-curtain look at the hedge fund industry, unlocking the most valuable stories, secrets, and lessons directly from those who have played the game best. Written by Maneet Ahuja, the hedge fund industry insider, The Alpha Masters brings the secretive world of hedge funds into the light of day for the first time. As the authority that the biggest names in the business, including John Paulson, David Tepper, and Bill Ackman, go to before breaking major news, Ahuja has access to the innermost workings of the hedge fund industry. For the first time, in Alpha Masters, Ahuja provides both institutional and savvy private investors with tangible, analytical insight into the psychology of the trade, the strategies and investment criteria serious money managers use to determine and evaluate their positions, and special guidance on how the reader can replicate this success themselves. There are few people with access to the inner chambers of the hedge fund industry, and as a result it remains practically uncharted financial territory. Alpha Masters changes all that, shedding light on star fund managers and how exactly they consistently outperform the market. The book: Contains easy-to-follow chapters that are broken down by strategy–Long/Short, Event Arbitrage, Value, Macro, Distressed, Quantitative, Commodities, Activist, pure Short, Fund of Funds. Includes insights from the biggest names in the trading game, including Ray Dalio, Marc Lasry, Jim Chanos, Sonia Gardner, Pierre Lagrange, and Tim Wong. Features contributions from industry icon Mohamed El-Erian Many of the subjects profiled in this groundbreaking new book have never spoken so candidly about their field, providing extremely provocative, newsworthy analysis of today's investing landscape.

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The Alpha Masters. Unlocking the Genius of the World's Top Hedge Funds

A simple, ten-step system for mastering the art of effective, persuasive business or technical writing «The Grahams' system is the best way to transform data and ideas into meaningful information necessary to make profitable decisions. Their system works every time.» —Steven Laposa, PhD, MBA, Loveland Commercial Endowed Chair in Real Estate, Colorado State University «The Grahams' straightforward program helps my teams create clear and concise reports, letters, and other documents with minimal effort. I want this program to become the standard for my teams.» —Bill Walter, Senior Vice President, Government and Infrastructure Division, KBR «The Can Do Writing system made my career! I used it to write a winning business plan and proposal, and now I use it every day for all communications. Can Do Writing provides valuable insights into business and management as well as writing techniques.» —Christian Robey, President, DC Progress You may be an expert at what you do, but if you can't communicate effectively in writing it may not matter. For scientists, businesspeople, and professionals in fields from engineering to public relations, the art of writing well can be a vital key to professional success. Luckily, you don't need an English degree to produce top-class writing. If you're one of the millions of people who have to write clear, persuasive, understandable documents for your job, Can Do Writing is for you. Whether you're writing a business plan, a scientific paper, a press release, or anything else, this simple, straightforward guide will show you how to do it quickly, with style and confidence. You'll learn how to: Understand your audience and subject matter Develop a simple, five-part purpose statement to keep you on track Organize your main points into a coherent, sensible order Edit your work for clarity, coherence, organization, and logic Economize your words to craft a concise, powerful document Make your documents easily readable for any audience

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Can Do Writing. The Proven Ten-Step System for Fast and Effective Business Writing

China Versus the West is an innovative book. The author, a leading specialist on the international and Asian economy and business, presents the most comprehensive picture of the changing power balance between the emerging superpower China and the «old» developed economies of the West: mainly the US, Europe and Japan. The reader can clearly see in what areas and to what extent China has become the world leader, in what areas it is catching up and in what areas the West retains its superiority and has a chance to strengthen it further. At the same time, I. Tselichtchev unveils a breath-taking story of the global economy and business in the brave new world which is non-"West-led" and where major growth dynamics are coming from large emerging economies. A radically changing economic environment requires new government policies and business strategies. The book contains many valuable suggestions and ideas. Using his own analytical framework, the author presents a set of options and alternatives for Western businesses in the wake of China's production and export offensive. The book provides a uniquely sharp and thought-provoking analysis of the factors behind the global crisis of 2008-2009, largely different from what we see in other publications, and examines its implications for the global power balance. I. Tselichtchev vividly shows that it was not global, but Western crisis of a structural character which drastically changed the China-West power balance in the former's favor. He provides strong arguments showing that today's China is structurally and macro-economically stronger than most countries of the West. This leads him to rethinking the very essence of the Chinese model of capitalism and to its new definition. He expresses unconventional, sometimes controversial, but well-founded views about China's problems and weaknesses and the prospects for its political evolution. The book ends with invaluable insights into China's unique role in the world economic history, the essence of the non-"West-led" multipolar world and the positions of its major players. Arguing that from now on no single country will be ever able to «rule the world», it shows new opportunities dynamic China is opening for the West. Thoroughly analyzing and discussing a wide range of the key, often complicated issues which are now in the focus of the world's attention, the book remains very reader-friendly. It is written in the form of an unconstrained dialogue with the reader, containing a lot of the author's on-the-spot impressions, interesting facts, remarks and quotations. China Versus the West is a must reading for everyone who wants to know more about the global developments, China and the West, and also, perhaps, to get valuable inputs and hints to find his or her own place in today's new world. It is highly recommended for policy-makers, business people, academics, analysts and journalists. It is a valuable source for professors and students of the universities and business schools.

China Versus the West. The Global Power Shift of the 21st Century

Providing exam focus and knowledge application makes The CFA® Level I Exam Companion the most effective study guide on the market. Wiley and Fitch Learning offer an invaluable self-study guide to passing one of the most sought-after designations in the finance industry. The CFA® Level I Exam Companion acts as a guide, assisting candidates to navigate through the wealth of CFA level I content, prioritising key areas of the official CFA texts. The Exam Companion has been written by Fitch Learning’s experienced CFA® instructor faculty, who know what it takes to pass. This important supplement provides: Exam focus and guidance from Fitch Learning CFA® instructors Exam style questions and worked examples demonstrating key concepts Identification of critical Learning Outcome Statements Directly references the CFA® curriculum Both the print and the e-book form part of the Exam Companion study suite that includes: – CFA® Level I: Study Session Apps (iOS, Android), – CFA® Level I: Are You Ready? App (iOS, Android) – Fitch Learning CFA® Course and Online Study Options There is no substitute for genuine experience. With a reputation for enthusiasm, professionalism and innovation, Fitch Learning prepares more than 3,000 people a year globally for the CFA® exams. With a comprehensive online portal, exam prep tablet, virtual or live classroom sessions, question banks and extensive study materials; Fitch Learning make sure you have everything you need to best prepare yourself for the CFA Level I Exam. Both the print and the e-book form part of a study suite that will include: – CFA Level I: Study Sessions App (iOS, Android), – CFA Level I: Are You Ready? App (iOS, Android) – and the FitchLearning CFA Digital Study Course. About the Apps: CFA Level I: Are You Ready? Considering adding CFA Level I to your CV? Are You Ready? by FitchLearning Wiley allows you to gauge your suitability for free, using 10 CFA Level I technical questions and a further 10 aptitude questions to examine your current financial knowledge and ability. Providing you with immediate results via diagnostic and video. CFA Level I: Study Sessions Offering the kind of support no other App on the market can match; CFA Level I Study Sessions by FitchLearning Wiley gives you a free reading from two of the most challenging topics in the curriculum; Financial Reporting & Analysis and Quantitative Methods. Candidates have the option to purchase the remaining readings from 6 study sessions across both topics, giving them access to entire modules on the move. The app incorporates lecture videos, annotated slide packs, questions and answers with the ability to track your progress and performance. All of this via stream or available to download and view offline, anywhere, anytime.

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CFA level I Exam Companion. The Fitch Learning / Wiley Study Guide to Getting the Most Out of the CFA Institute Curriculum

Reorient your selling approach Mr. Shmooze is the parable of a man who reveals the secret shared by all superstar salespeople. Selling, in its most exquisite form, is not about “taking,” nor is it about “persuading.” Selling, believe it or not, is about “giving.” Mr. Shmooze gives for a living. He starts by listening and he quickly comes to understand what people really need. His customers love him because he gives more than he takes. They trust him because he is passionate about their interests. And, at the end of the day, they reward him handsomely for bringing joy, humor and wisdom into their lives. Woven into the story are several powerful lessons for salespeople in all industries who attempt to build relationships as the emotional bridge to their clients. • Bring extraordinary passion and energy to personal communications • Generate contagious, positive feelings, lifting spirits because people buy with their emotions • Make the small, positive gestures that can lead to huge, long-term results • Abraham has had a diverse business career that has established him as a well-known expert on what makes high-performing salespeople Mr. Shmooze gives you the new approach you need to sell like you’ve never sold before!

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Mr. Shmooze. The Art and Science of Selling Through Relationships

Silver Medal Winner, Success and Motivation, 2012 Axiom Business Book Awards An essential guide for mastering failure in order to achieve your goals Success is often just a moment—a goal fulfilled, soon to be replaced with new goals. But failure is the ambitious person's constant companion, often dogging us for months, years or even decades before we finally reach our aim. In the groundbreaking book Why People Fail, Siimon Reynolds, one of the world's most successful entrepreneurs, explores the main causes of failure, in any field, and reveals solutions for overcoming them and creating a successful personal and professional life. Why People Fail offers strategies and ideas for defeating the sixteen most common failure habits such as destructive thinking, low productivity, stress, fixed mindset, lack of daily rituals, and more. Outlines the common habits that lead to failure and shows how to overcome them Features dozens of tips and exercises to help increase business and personal success Written by Siimon Reynolds, an internationally recognized expert on high performance and business excellence Many people have changed their lives by mastering just one of the timeless principles in this book. Master five or ten and your life will rocket to a totally new level.

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WASHINGTON POST Bestseller List 3/30/14 Solid solutions and step-by-step instructions for planning the next stage of your life Life after 50 isn’t what it used to be. The rules have changed. No more guaranteed pensions, retiree health plans, or extensive leisure and travel. It’s time to forge new paths and create innovative models. That’s where the AARP Roadmap for the Rest of Your Life comes in. Bart Astor, author of more than a dozen books, offers a comprehensive guide for making lifestyle decisions, growing your nest egg, and realizing your goals. This AARP book— Provides guidance on the key areas you’ll need to consider: finances and work, health and fitness, Medicare and Social Security, estate planning, insurance, housing, and more Offers expert tips on creating age- and health-specific goals through a personal “Level of Activity” scale based on how active you can and want to be Includes tips for finding fun and fulfilling activities and even completing your bucket list Supplies ready-to-use worksheets to help you set and meet financial planning goals, get your legal affairs in order, and maintain adequate health insurance Contains a comprehensive list of valuable resources 

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AARP Roadmap for the Rest of Your Life. Smart Choices About Money, Health, Work, Lifestyle .. and Pursuing Your Dreams

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Epithelial Anion Transport in Health and Disease

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