Derek J. Chadwick

A comprehensive review of current thinking on the biosynthesis, function and evolution of secondary metabolites in animals, plants and microorganisms. Examines the traditional context of secondary metabolites as natural products having no obvious par…

Cl- absorption and HCO3- secretion are intimately associated processes vital to epithelial function, itself a key physiological activity. Until recently the transporters responsible remained obscure, but a breakthrough occurred with the discovery of …

Recent application of the techniques of molecular biology and patch-clamp physiology has led to rapid advances in understanding the molecular events in chemosensory transduction. In this book, the latest results are presented and discussed by leading…

Using a multidisciplinary approach, it combines anatomical, cellular and physiological studies by preeminent experts. Features important insights into the function of the hypothalamus.

The heat shock, or cell stress, response was first identified in the polytene chromosomes of Drosophila. This was later related to the appearance of novel proteins within stressed cells, and the key signal stimulating this appearance was identified a…

The heat shock, or cell stress, response was first identified in the polytene chromosomes of Drosophila. This was later related to the appearance of novel proteins within stressed cells, and the key signal stimulating this appearance was identified a…

The mapping of human genes is proceeding rapidly. Genes associated with specific inherited diseases are being identified, often providing insight into the molecular cause of the disease. At the moment, however, little consideration is being given to …

Examines the establishment of the germ layers and other cell lineages in the early embryo including details of cell movements during the beginning stages of primitive streak formation. Discusses patterns of gene expression during the development of s…

Prestigious contributors describe the genetic, molecular, anatomical and neurochemical mechanisms and pathways that operate to regulate and control circadian rhythmicity and functioning in organisms ranging from unicellular algae to human beings. Als…

This book brings together contributions from key investigators in the area of pathological pain. It covers the molecular basis of receptors and channels involved in nociception, the possible messages that cause neuropathic plasticity, spinal plastici…

The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour format…

Epigenetics pertains to the development of an organism from an undifferential cell, resulting in the successive formation and development of organs and parts that did not pre-exist in the fertilized egg. An exciting and stimulating volume which used …

Asthma is a growing health problem throughout the developed world. This volume presents a critical review of all the possible factors for this rising trend and includes research that has not yet been published in the scientific literature. Discusses …

An interdisciplinary and multinational group of specialists present contributions describing the current status of vaccines against virally induced tumors and discuss the means by which they can be improved.

Microbial responses to acidic and alkaline pH are important in many areas of bacteriology. For example, the mechanisms of resistance to acidic pH are important in the understanding of the passage of human pathogens through the acid of the stomach; an…

This exciting book brings together an international and interdisciplinary group of experts to discuss the importance of pulsatile signalling in the induction of biological responses. Coverage includes the basic mechanisms involved in hormone pulsatil…

T cells are a specialized population of immune cells that aid the immune system in combating various types of invading pathogens. This book presents up-to-the-minute data on the role of T cells in autoimmune diseases.

The field of neural transplantation is at a crucial stage, with important clinical trials on transplantation in patients with Parkinson's disease nearing completion and novel, alternative approaches to fetal transplantation being developed. This time…

Reviews recent basic research into IgE, mast cells, and the allergic response and the relevance of this work to human pathophysiology, and discusses new methods of treatment. This symposium is unique in the IgE field for its breadth of coverage and i…

Prominent contributors address issues regarding the toxicity of aluminum which causes an encephalopathy in renal dialysis patients and is also known to damage animals and plants via acid rain. Examines the chemistry and biology of aluminum compounds …