Breakthroughs in combinatorial chemistry and molecular biology, as well as an overall industry trend toward accelerated development, mean the rate of sample generation now far exceeds the rate of sample analysis in the pursuit of producing new and better pharmaceuticals. LC/MS is an analytical tool that helps the researcher identify the most promising sample early in the selection process, effectively creating a shortcut to finding new drugs. This book is the first to describe LC/MS applications within the context of drug development, including the discovery, preclinical, clinical, and manufacturing phases. In addition to the thorough technical analysis of this tool, LC/MS Applications in Drug Development provides perspective on the significant changes in strategies for pharmaceutical analysis. A process overview of drug development from an analytical point of view is provided along with essential data required to successfully bring a drug to market. The incorporation of LC/MS is illustrated from target to product. Chapters pertaining to the discovery process itself include: Proteomics Glycoprotein Mapping Natural Products Dereplication Lead Identification Screening Open-Access LC/MS In Vitro Drug Screening Written for both the analytical chemist who uses LC/MS applications and the pharmaceutical scientist who works with the drugs they produce, LC/MS Applications in Drug Development is the premier reference on the subject.

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LC/MS Applications in Drug Development

Proteomic Biology Using LC/MS

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Building an analysis ecosystem for a smarter approach to intelligence Keith Carter's Actionable Intelligence: A Guide to Delivering Business Results with Big Data Fast! is the comprehensive guide to achieving the dream that business intelligence practitioners have been chasing since the concept itself came into being. Written by an IT visionary with extensive global supply chain experience and insight, this book describes what happens when team members have accurate, reliable, usable, and timely information at their fingertips. With a focus on leveraging big data, the book provides expert guidance on developing an analytical ecosystem to effectively manage, use the internal and external information to deliver business results. This book is written by an author who's been in the trenches for people who are in the trenches. It's for practitioners in the real world, who know delivering results is easier said than done – fraught with failure, and difficult politics. A landscape where reason and passion are needed to make a real difference. This book lays out the appropriate way to establish a culture of fact-based decision making, innovation, forward looking measurements, and appropriate high-speed governance. Readers will enable their organization to: Answer strategic questions faster Reduce data acquisition time and increase analysis time to improve outcomes Shift the focus to positive results rather than past failures Expand opportunities by more effectively and thoughtfully leveraging information Big data makes big promises, but it cannot deliver without the right recipe of people, processes and technology in place. It's about choosing the right people, giving them the right tools, and taking a thoughtful—rather than formulaic–approach. Actionable Intelligence provides expert guidance toward envisioning, budgeting, implementing, and delivering real benefits.

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Actionable Intelligence. A Guide to Delivering Business Results with Big Data Fast!

How to reach the 98 percent of people who leave your website without converting sales The Retargeting Playbook is a complete guide for digital marketers about how to reach the 95 to 98 percent of people who leave a brand's website without converting. Retargeting gives advertisers the ability to stay in front of those people to bring them back and close the deal. For that reason, retargeting has emerged as a must have marketing channel, yet there is a lack of content that explains how the technology actually works and best practices for using it. Even marketing managers at large, sophisticated brands and agencies don’t have a strong grasp of this evolving channel, and there are few good neutral sources on the topic. Meanwhile, retargeting is the cornerstone of any holistic digital advertising strategy since it improves the results of every other channel if implemented correctly. Unfortunately, most marketers are only utilizing the most rudimentary retargeting tactics and barely scratch the surface of its potential. Explains how to stay in front of potential customers and convince them to come back and close the deal This book will be required reading for media buyers at digital agencies, in-house marketing managers at companies in any vertical, performance marketers, and ecommerce managers.

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The Retargeting Playbook. How to Turn Web-Window Shoppers into Customers

Almost 70% of mergers fail, yet deals are essential for growing world-class companies. Therefore they must use all the tools and techniques at their disposal to improve their chances of success. Applying the techniques advocated in this book can help managers beat the odds – and employees themselves – to have an impact on whether a deal will be successful both for the company and for themselves. This book looks at the process of a merger or acquisition and pinpoints the areas where business intelligence can raise the odds of success in each phase of the deal. Using techniques developed by governmental intelligence services and a wide range of recent case studies, quotations and anecdotes, the expert authors from the renowned Cass Business School show how to build success into any M&A situation. The first edition of Intelligent M&A was written in 2006 and published in 2007. This preceded the peak year (2007) of the last merger wave, including the excesses in a number of industries and deals (e.g., financial services with RBS’ dramatically failed acquisition of ABN AMRO as a key example), and the global economic downturn that led to a completely new way of operating for many industries and companies. Therefore, there is a need to update the book to incorporate not just more relevant and up-to-date case studies of deals but to show the ‘new’ way of operating in a post-Lehman environment. Chapters will be comprehensively re-written and populated with new and relevant case studies.

Intelligent M & A. Navigating the Mergers and Acquisitions Minefield

Describes the world's leading approach to art and design taught at Rhode Island School of Design At Rhode Island School of Design students are immersed in a culture where making questions, ideas, and objects, using and inventing materials, and activating experience all serve to define a form of critical thinking—albeit with one's hands—i.e. «critical making.» The Art of Critical Making, by RISD faculty and staff, describes fundamental aspects of RISD's approach to «critical making» and how this can lead to innovation. The process of making taught at RISD is deeply introspective, passionate, and often provocative. This book illuminates how RISD nurtures the creative process, from brief or prompt to outcome, along with guidance on the critical questions and research that enable making great works of art and design. Explores the conceptual process, idea research, critical questions, and iteration that RISD faculty employ to educate students to generate thoughtful work Authors are from the faculty and staff of the Rhode Island School of Design, which consistently ranks as the number one fine arts and design college in the United States The Art of Critical Making shows you how context, materials, thought processes, and self-evaluation are applied in this educational environment to prepare creative individuals to produce dynamic, memorable, and meaningful works.

The Art of Critical Making. Rhode Island School of Design on Creative Practice

A smarter framework for designing more effective workplace wellness programs Workplace Wellness That Works provides a fresh perspective on how to promote employee well-being in the workplace. In addressing the interconnectivity between wellness and organizational culture, this book shows you how to integrate wellness into your existing employee development strategy in more creative, humane, and effective ways. Based on the latest research and backed by real-world examples and case studies, this guide provides employers with the tools they need to start making a difference in their employees' health and happiness, and promoting an overall culture of well-being throughout the organization. You'll find concrete, actionable advice for tackling the massive obstacle of behavioral change, and learn how to design and implement an approach that can most benefit your organization. Promoting wellness is a good idea. Giving employees the inspiration and tools they need to make changes in their lifestyles is a great idea. But the billion-dollar question is: what do they want, what do they need, and how do we implement programs to help them without causing more harm than good? Workplace Wellness That Works shows you how to assess your organization's needs and craft a plan that actually benefits employees. Build an effective platform for well-being Empower employees to make better choices Design and deliver the strategy that your organization needs Drive quantifiable change through more creative implementation Today's worksite wellness industry represents a miasma of competing trends, making it nearly impossible to come away with tangible solutions for real-world implementation. Harnessing a broader learning and development framework, Workplace Wellness That Works skips the fads and shows you how to design a smarter strategy that truly makes a difference in employees' lives—and your company's bottom line.

Workplace Wellness that Works. 10 Steps to Infuse Well-Being and Vitality into Any Organization

Help your students succeed with classroom-ready, standards-based activities The Algebra Teacher's Activities Kit: 150 Activities That Support Algebra in the Common Core Math Standards helps you bring the standards into your algebra classroom with a range of engaging activities that reinforce fundamental algebra skills. This newly updated second edition is formatted for easy implementation, with teaching notes and answers followed by reproducibles for activities covering the algebra standards for grades 6 through 12. Coverage includes whole numbers, variables, equations, inequalities, graphing, polynomials, factoring, logarithmic functions, statistics, and more, and gives you the material you need to reach students of various abilities and learning styles. Many of these activities are self-correcting, adding interest for students and saving you time. This book provides dozens of activities that Directly address each Common Core algebra standard Engage students and get them excited about math Are tailored to a diverse range of levels and abilities Reinforce fundamental skills and demonstrate everyday relevance Algebra lays the groundwork for every math class that comes after it, so it's crucial that students master the material and gain confidence in their abilities. The Algebra Teacher's Activities Kit helps you face the challenge, well-armed with effective activities that help students become successful in algebra class and beyond. 

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Algebra Teacher's Activities Kit. 150 Activities that Support Algebra in the Common Core Math Standards, Grades 6-12

Be a more effective leader with strategic thinking Leading with Strategic Thinking reveals what effective leaders do differently. Eschewing the one-size-fits-all leadership model, this helpful guide outlines four general leadership types and demonstrates how each type achieves success – whether through personal vision, structured process, collaboration, or by empowering others. The authors identify the actions and skills that distinguish strategic leadership, drawn from interviews and focus groups with over three hundred leaders from around the world. Examples and case studies illustrate these concepts in action, and the provided reference materials steer readers toward more advanced information on this important topic. The disruptive forces of technology and globalization raise new challenges for leaders. This book is a manual that will help executives and aspiring leaders harness these forces and address the two central questions of strategic leadership: How do the best leaders develop their strategy? How do effective leaders drive strategic change? Becoming a strategic leader isn’t about mimicking an icon. The most effective leaders seize opportunity in a way that consciously integrates environmental requirements, stakeholder expectations, and personal ability. Leading with Strategic Thinking shows what these leaders do, and gives anyone the tools to be a more strategic leader.

Leading with Strategic Thinking. Four Ways Effective Leaders Gain Insight, Drive Change, and Get Results

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