В монографии приведены основные биолого-физиологические закономерности развития, функции, механизмы и виды дифференцировки стволовых клеток, их способность к размножению и генерации потомства на уровне популяции. Дается краткое обоснование двух принципиально разных типов стволовых клеток: плюрипотентных, которые существуют только in vitro, и тканевых, существующих in vivo в послеродовом организме. Показано, что плюрипотентные клетки могут приводить к появлению широкого спектра типов клеток, в отличие от тканевых, которые в нормальных условиях не генерируют клетки, характерные для других типов тканей. Представлены этапы развития плюрипотентных стволовых клеток. Обсуждается роль ключевых маркеров плюрипотентности и факт того, что самым надежным способом идентификации стволовых клеток является определение их фенотипа in vivo. Это свидетельствует о том, что стволовые клетки не несут универсального молекулярного маркера, позволяющего дифференцировать стволовые клетки от нестволовых. Рассмотрены объекты и современные методы редактирования генома. Охарактеризована иммунная система прокариот и их защитные механизмы, препятствующие целевому редактированию генома в интересах исследователя. Описаны фазы развития эмбриона, начиная с формирования гамет и зародышевых линий, различия в отборе зародышевых и соматических клеток, рассматривается образование истинных зародышевых клеток, их типы, факторы, обеспечивающие их дифференцировку и миграцию. Представлены проблемные и перспективные сведения по использованию стволовых клеток в трансплантологии и другие не менее интересные вопросы, касающиеся стволовых клеток.
Монография предназначена биологам, физиологам, врачам, научным работникам, будет полезна преподавателям, аспирантам и студентам биологических и медицинских факультетов университетов, академий и институтов, а также широкому кругу читателей.

учебная и научная литература

монографии

биология

микробиология

знания и навыки

Стволовые клетки: биолого-физиологические закономерности развития, функции и механизмы

любовные романы

фэнтези

современная русская литература

современные любовные романы

современная зарубежная литература

детективы

об истории серьезно

приключения

книги о приключениях

ужасы / мистика

учебники и пособия для вузов

cтихи, поэзия

книги по психологии

стихи и поэзия

гуманитарные и общественные науки

русская классика

мистика

боевики, остросюжетная литература

публицистическая литература

Almost every modern manufacturing process relies on industrial gases, and sales of such gases are expected to rise by around 45% over the next five years. Here, experienced and authoritative experts from one of the two world's largest producer of industrial gases impart their knowledge on atmospheric, noble and synthesized gases, carbon dioxide, LNG, acetylene and other fuel gases, as well as special and medical gases. Modern applications, e.g., the use of hydrogen in fuel cells, are included as well. This practical text is rounded off by a section on logistics.

научно-популярная литература

зарубежная образовательная литература

Industrial Gases Processing

This IAS Special Publication contains 23 papers presented at the 3rd International Research Symposium on Modern and Ancient Clastic Tidal Deposits. This symposium series has an enviable international reputation for its quality, and so the contributions represent the latest developments in the field. The conference was preceded and followed by a number of field trips to some of the most prominent tidal flat and barrier island systems of continental Europe, and these have been written up as overview papers that summarize the current state of knowledge about these various tidal regions. The latest research results from this very specialized field. If you are a member of the International Association of Sedimentologists, for purchasing details, please see: http://www.iasnet.org/publications/details.asp?code=SP24

Tidal Signatures in Modern and Ancient Sediments (Special Publication 24 of the IAS)

Validation describes the procedures used to analyze pharmaceutical products so that the data generated will comply with the requirements of regulatory bodies of the US, Canada, Europe and Japan. Calibration of Instruments describes the process of fixing, checking or correcting the graduations of instruments so that they comply with those regulatory bodies. This book provides a thorough explanation of both the fundamental and practical aspects of biopharmaceutical and bioanalytical methods validation. It teaches the proper procedures for using the tools and analysis methods in a regulated lab setting. Readers will learn the appropriate procedures for calibration of laboratory instrumentation and validation of analytical methods of analysis. These procedures must be executed properly in all regulated laboratories, including pharmaceutical and biopharmaceutical laboratories, clinical testing laboratories (hospitals, medical offices) and in food and cosmetic testing laboratories.

Analytical Method Validation and Instrument Performance Verification

Provides comprehensive coverage of microneedles for delivering and monitoring patient drugs and vaccines Microneedles are an incredibly active research area and have the potential to revolutionize the way many medicines and vaccines are delivered. This comprehensive research book covers the major aspects relating to the use of microneedle arrays in enhancing both transdermal and intradermal drug delivery and provides a sound background to the use of microneedle arrays in enhanced delivery applications. Beginning with a history of the field and the various methods employed to produce microneedles from different materials, Microneedles for Drug and Vaccine Delivery and Patient Monitoring discusses the penetration of the stratum corneum by microneedles and the importance of application method and force and microneedle geometry (height, shape, inter-needle spacing). Transdermal and intradermal delivery research using microneedles is comprehensively and critically reviewed, focusing on the outcomes of in vivo animal and human studies. The book describes the important topics of safety and patient acceptability studies carried out to date. It also covers in detail the growing area for microneedle use in the monitoring of interstitial fluid contents. Finally, it reviews translational and regulatory developments in the microneedles field and describes the work ongoing in industry. The only book currently available on microneedles Filled with tables, graphs, and black and white images (photographs, micrographs) Authored by four experts in pharmaceutics Microneedles for Drug and Vaccine Delivery and Patient Monitoring is an ideal source for researchers in industry and academia working on drug delivery and transdermal delivery in particular, as well as for advanced students in pharmacy and pharmaceutical sciences.

Microneedles for Drug and Vaccine Delivery and Patient Monitoring

The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects – properties, synthesis, reactions, physiological and industrial significance – of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.

The Chemistry of Heterocyclic Compounds, Fused Pyrimidines

The formation, dispersal and germination of seeds are crucial stages in the life cycles of gymnosperm and angiosperm plants. The unique properties of seeds, particularly their tolerance to desiccation, their mobility, and their ability to schedule their germination to coincide with times when environmental conditions are favorable to their survival as seedlings, have no doubt contributed significantly to the success of seed-bearing plants. Humans are also dependent upon seeds, which constitute the majority of the world’s staple foods (e.g., cereals and legumes). Seeds are an excellent system for studying fundamental developmental processes in plant biology, as they develop from a single fertilized zygote into an embryo and endosperm, in association with the surrounding maternal tissues. As genetic and molecular approaches have become increasingly powerful tools for biological research, seeds have become an attractive system in which to study a wide array of metabolic processes and regulatory systems. Seed Development, Dormancy and Germination provides a comprehensive overview of seed biology from the point of view of the developmental and regulatory processes that are involved in the transition from a developing seed through dormancy and into germination and seedling growth. It examines the complexity of the environmental, physiological, molecular and genetic interactions that occur through the life cycle of seeds, along with the concepts and approaches used to analyze seed dormancy and germination behavior. It also identifies the current challenges and remaining questions for future research. The book is directed at plant developmental biologists, geneticists, plant breeders, seed biologists and graduate students.

Annual Plant Reviews, Seed Development, Dormancy and Germination

Now available in paperback. This revised and updated edition of the definitive resource for experimental psychology offers comprehensive coverage of the latest findings in the field, as well as the most recent contributions in methodology and the explosion of research in neuroscience. Volume One: Sensation and Perception focuses on sensory experience and complex learned perceptions through modalities such as vision, touch, smell, and hearing.

общая психология

Stevens' Handbook of Experimental Psychology, Sensation and Perception

Полная версия

Стволовые клетки: биолого-физиологические закономерности развития, функции и механизмы