Over the past two decades the benefits of label-free biosensor analysis have begun to make an impact in the market, and systems are beginning to be used as mainstream research tools in many drug discovery laboratories. Label-Free Technologies For Drug Discovery summarises the latest and emerging developments in label-free detection systems, their underlying technology principles and end-user case studies that reveal the power and limitations of label-free in all areas of drug discovery. Label-free technologies discussed include SPR, NMR, high-throughput mass spectrometry, resonant waveguide plate-based screening, transmitted-light imaging, isothermal titration calorimetry, optical and impedance cell-based assays and other biophysical methods. The technologies are discussed in relation to their use as screening technologies, high-content technologies, hit finding and hit validation strategies, mode of action and ADME/T, access to difficult target classes, cell-based receptor/ligand interactions particularly orphan receptors, and antibody and small molecule affinity and kinetic analysis. Label-Free Technologies For Drug Discovery is an essential guide to this emerging class of tools for researchers in drug discovery and development, particularly high-throughput screening and compound profiling teams, medicinal chemists, structural biologists, assay developers, ADME/T specialists, and others interested in biomolecular interaction analysis.

технические науки

медицина / здравоохранение

фармакология

нормативная документация

Label-Free Technologies For Drug Discovery

любовные романы

фэнтези

учебная и научная литература

современная русская литература

современные любовные романы

современная зарубежная литература

детективы

об истории серьезно

приключения

книги о приключениях

ужасы / мистика

учебники и пособия для вузов

cтихи, поэзия

книги по психологии

стихи и поэзия

гуманитарные и общественные науки

русская классика

мистика

боевики, остросюжетная литература

публицистическая литература

В последние годы нейросети стали неотъемлемой частью нашей жизни. Они используются в различных областях, от распознавания изображений и речи до принятия решений и прогнозирования. Но какое воздействие оказывают нейросети на нашу жизнь? Как они меняют нашу работу, наше общение и наше общество? В этой книге мы рассмотрим различные аспекты воздействия нейросетей на жизнь человека, от их применения в медицине и образовании до их влияния на нашу психику и социальные отношения.

книги о компьютерах

Нейросети: Революция в жизни человека

Стремление к далеким вершинам – похвальное занятие. Новые изобретения дают их создателям уверенность в себе. Однако, когда жизнь вне науки рушится и сводит с ума, радость от своих достижений меркнет, а восприятие окружающего мира становится мрачным и циничным.

научная фантастика

детективная фантастика

Источник энергии

«Последний бой Птеродактиля» - это пародия на героический киберпанк, в котором главное действующее лицо, смелый и креативный Супервайзер, спасает человечество от неминуемой энергетической катастрофы. Попутно он уничтожает злобных пришельцев – чёрную Плесень из чёрной космической дыры, а также их предводителя Кощея, считавшегося до этого бессмертным. И ещё один подвиг совершает герой – он освобождает, заколдованную в Гадюку и томившуюся у злодея в темнице, красавицу и мажорку.

киберпанк

Последний бой Птеродактиля

How senior leaders can re-connect to the emerging leaders hidden in their organizations A sea change has taken place throughout the culture of leadership; today’s emerging leaders are «opting out» of the same positions their predecessors coveted in years past. But many senior managers trained in traditional leadership still hang onto outdated approaches of command and control despite how much they’ve heard about «empowerment» and inclusion. At the core of this book is the fictional suspense story of Brookreme Corporation, whose leaders are challenged to chart a course to a global future, navigating relational land mines along the way. With both story telling and hard research, Leadership Divided reconnects generations and instructs both senior and emerging leaders on how the relationships of the future will be the path to revolutionary performance. Ron A. Carucci (Seattle, WA) is a founding partner with Passages Consulting, LLC, where he works with CEOs and senior executives in pursuit of profound organizational change and executive leadership capability. He is Graduate Professor of Leadership at Mars Hill Graduate School in Seattle. He is also faculty member at Fordham University, serving as Associate Professor of Organizational Behavior, and has served as an adjunct at the Center for Creative Leadership. His clients have included Edward Jones Investments, Bristol-Myers Squibb, Amgen, McDonald’s, PepsiCo, Gates Corporation, Accenture, and many others.

зарубежная деловая литература

Leadership Divided. What Emerging Leaders Need and What You Might Be Missing

Praise for America's Corner Store «Who would have thought the story of a drugstore chain could encompass so much vital and fascinating American history? With superb storytelling skills, John Bacon gives us a vivid and insightful chronicle of matters both large and small, from the birth of the milkshake to the rise of America's consumer culture. America's Corner Store is a genuine treat.» -James Tobin the National Book Critics' Circle–Award winner, and author of To Conquer the Air: The Wright Brothers and the Great Race for Flight «Run the business with your head. Lead the family with your heart. Walgreens' history is filled with good values, strong principles, and immense courage. A family business classic.» -Howard «Howdy» S. Holmes President and CEO, «Jiffy» Mixes «John Bacon has crafted a thorough, insightful, readable, and fascinating account of the development of Walgreens: one of the world's most compelling examples of the creation of shareholder value in conjunction with good corporate governance… all in a company run in a highly unique fashion as a 'family' business. As the store that everyone knows, Walgreens has become the envy of corporate America and the darling of shareholders, consistently producing investor returns that place it at the very top among its peers. This book will be required reading in my private equity class at Michigan Business School.» -Professor David Brophy Director, Center for Venture Capital and Private Equity Finance, University of Michigan Business School 

дистрибуция

управление продажами

America's Corner Store. Walgreen's Prescription for Success

Hire with Your Head Updated with new case studies and more coverage of the impact and importance of the Internet in the hiring process, this indispensable guide has shown tens of thousands of managers and human resources professionals how to find the perfect candidate for any position. Lou Adler's Performance-based Hiring is more powerful than ever! «We have chosen Performance-based Hiring because it's a comprehensive process, it's behaviorally grounded, managers and recruiters find it easy to use, and it works.» -Marshall Utterson, Director Staffing, AIG Enterprise Services, LLC «Everyone's looking for the perfect means to make effective hiring decisions. A trained interviewer armed with the right tools is the best solution. Performance-based Hiring is a proven methodology to get these results.» -John Ganley, Vice President and Chief Talent Officer, Quest Software «Any staffing director that doesn't send all of their people through Performance-based Hiring training is missing out on top talent, plain and simple. This should be the standard throughout the industry.» -Dan Hilbert, Recruiting Manager, Valero Energy Corporation «Performance-based Hiring has been the most successful recruitment tool that we have added to our organization over the past few years. In fact, these tools have not only produced amazing outcomes-in terms of selecting the best fit in an extremely tight labor market-but with a level of success among our operations customers that I have rarely seen with other HR products.» -Trudy Knoepke-Campbell, Director, Workforce Planning, HealthEast(r) Care System 

управление бизнесом

управление персоналом

Hire With Your Head. Using Performance-Based Hiring to Build Great Teams

At first, Mark Prothero, Defense Attorney for Gary Ridgway, thought: «This can't be the Green River Killer! He's too ordinary! He's too small. He's too calm. He's too polite! He can't possibly have murdered forty-nine women. They can't be serious! They must have screwed up! I didn't realize then, but I was right. Gary Ridgway hadn't killed forty-nine women. He'd killed even more than that.» Soon, Mark Prothero faced the question: «How could you possibly defend the most prolific serial killer in United States history, the infamous Green River Killer? If anyone deserved to be executed for his crimes, didn't he?» Mark Prothero, co-lead defense attorney who helped save Gary Ridgway from the death sentence, has heard that question many times. Now he’s written a book that reveals the true, inside story of exactly how an idealistic public defender, high school swim coach, husband, and dad could bring himself to spend many months of close confinement with a man who brutally murdered at least 75 young women, often in the act of sex. Defending Gary shows how Prothero could reconcile these monstrous acts knowing the reality of this unassuming fellow Gary Ridgway, a mild-mannered, church-going, devoted husband, father, and former Navy man, with an IQ of around 82 and a longtime job as a truck painter from Auburn, Washington, near Seattle.

зарубежная образовательная литература

знания и навыки

Defending Gary. Unraveling the Mind of the Green River Killer

Полная версия

Label-Free Technologies For Drug Discovery