As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices


медицина / здравоохранение

фармакология

Drug Discovery Toxicology. From Target Assessment to Translational Biomarkers

Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants

Drug-Induced Mitochondrial Dysfunction

любовные романы

фэнтези

учебная и научная литература

современная русская литература

современные любовные романы

современная зарубежная литература

детективы

об истории серьезно

приключения

книги о приключениях

ужасы / мистика

учебники и пособия для вузов

cтихи, поэзия

книги по психологии

стихи и поэзия

гуманитарные и общественные науки

русская классика

мистика

боевики, остросюжетная литература

публицистическая литература

Стихи в Заплатках – это обнажённая душа, собранная по кусочкам. Как старый плюшевый зайчик, израненный жизнью и бережно залатанный любовью, эти стихи не скрывают своих шрамов. Здесь каждая строчка – это стежок, соединяющий боль и надежду, отчаяние и веру в лучшее. Это книга для тех, кто не боится быть уязвимым, кто ищет утешение в словах и кто верит, что даже самые глубокие раны можно исцелить.

Стихи в заплатках

На кухне нет места компромиссам. Когда привычные методы не работают, настоящий творец идёт до конца, чего бы ему это не стоило. Его последнее блюдо станет либо триумфом, либо смертным приговором. Bon appétit, если осмелитесь.

триллеры

Ты – то, что ты ешь

В центре сюжета — неожиданное и значимое прикосновение, которое становится мостом к новым чувствам и переменам в отношениях. В окружении природы и в спокойной атмосфере заката они переживают особое мгновение, символизирующее начало новой главы, основанной на доверии и взаимном понимании. В этом эпизоде подчеркнута важность простых, но значимых моментов жизни, способных навсегда оставить след в сердцах и стать напоминанием о ценности настоящего счастья — быть рядом и делить радости и переживания.

зарубежные любовные романы

зарубежная драматургия

Океан в глазах.

How good companies build a culture of integrity In the present environment of corporate governance brought on by high-profile executive scandals, this book makes a strong case for encouraging business leaders to manage beyond compliance. Achieving the bare minimum of compliance isn't enough. By making corporate responsibility and integrity a strategic priority-rather than something companies are forced to comply with-companies can realize tangible financial returns and benefits. This book provides practical advice, effective tools, and time-tested best practices for approaching corporate integrity strategically and managing an integrity program on a day-to-day basis. There is a growing realization that compliance with the rules is only a minimum standard of performance, and an increasing demand from stakeholders at every level – shareholders, employees, customers along the entire supply chain, consumers, advocacy groups, and the local community at large – for more transparency and accountability from corporations. But most businesses have little experience and few tools to deal with the urgent demand to increase corporate responsibility. Corporate Integrity provides practical tools and proven processes to manage complex integrity dilemmas and support implementation: Explains how to create a culture of integrity in your organization and how to motivate the appropriate corporate behaviors. Coverage includes: How to assess and measure integrity; how to align corporate integrity commitments and actions; how to design and implement dependable and strategic corporate accountability systems and processes; how to develop corporate integrity standards and report on them, and much more. Includes a wealth of practical business tools and best practices that readers can apply to improve the level of corporate integrity in their own company. Features three detailed case studies and numerous other examples that illustrate corporate integrity dilemmas and solutions in action. Shows how managing corporate responsibility strategically and proactively can go beyond a mere public relations exercise to foster a corporate «win» in the court of popular opinion and in the marketplace. Bridges the gaps between corporations, governments, employees, interest groups, and consumers. Offers tools and solutions that apply to both for-profit corporations and non-profit organizations. 

зарубежная деловая литература

Corporate Integrity. A Toolkit for Managing Beyond Compliance

Card games offer loads of fun and one of the best socializing experiences out there. But picking up winning card strategies is a bit of a challenge, and though your buddies may think that picking up the rules of the game is easy, winning is a totally different story. With Card Games For Dummies, Second Edition, you’ll not only be able to play the hottest card games around, you can also apply game-winning strategies and tips to have fun and beat your opponents. Now updated, this hands-on guide shows you everything you need to know—the basics, the tricks, and the techniques—to become a master card player, with expanded coverage on poker as well as online gaming and tournaments. Soon you will have the card-playing power to: Pin down your opponents in Texas Hold’em Show off your power in Stud Poker Hit wisely in Blackjack Break hearts ruthlessly in Hearts Mix up the night with Gin and Rummy Build yourself a victory in Bridge Send them fishing in Go Fish This straightforward, no-nonsense guide features great ways to improve your game and have more fun, as well as a list of places to find out more about your favorite game. It also profiles different variations of each game, making you a player for all seasons!

развлечения

хобби, досуг

Card Games For Dummies

If you’re feeling overwhelmed by the prospect of getting a dog or nervous about caring for the one you’ve already brought home, now you can relax. Understanding Your Dog for Dummies helps you recognize not only why your dog behaves the way she does, but in a way that enables you to parlay that into a well-behaved companion who listens (and sits, and speaks, and comes, etc.). Whether your pooch is a mixed breed or purebred, she has a distinct identity that makes her unique. The first step in understanding your dog is to respect the honorable task she was originally bred for and to identify how these inbred impulses influence her personality and behavior. In essence, you need to speak her language if you expect her to learn to understand yours. Understanding Your Dog for Dummies gives you everything you need to learn to understand your pooch’s unique dialect of “Doglish”—and shows you how to take on the role as pack leader to give your dog the cues, guidance, and consistency she needs to shape and develop good behaviors. Inside you’ll discover how to: Read your dog’s body language Communicate with your dog Interpret your dog’s breed-specific traits Correct dog-behavior-gone-bad Counter anxiety-based behavior Understand and resolve aggressive behavior And so much more! Think of this book as Doglish 101—a prerequisite for every human member of your dog’s family. Now, let the training begin!

домашние животные

дом, дача

Understanding Your Dog For Dummies

In Point, Click & Wow! you will find the insider knowledge of public speaking that we all need but were never taught. When Point, Click & Wow! was first published more than ten years ago, it quickly became the go-to resource for creating laptop presentations that have the «Wow» factor! Completely reworked and updated, this new third edition puts the focus on you, the presenter, who must create a winning presentation every time. Claudyne Wilder's groundbreaking book offers myriad new features and updated slide designs as well as illustrative stories and advice from executives. Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.

стратегический менеджмент

Point, Click and Wow!. The Techniques and Habits of Successful Presenters

Полная версия

Drug Discovery Toxicology. From Target Assessment to Translational Biomarkers

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