#133 – Manolis Kellis: Biology of Disease

Manolis Kellis is a computational biologist at MIT. Please support this podcast by checking out our sponsors: - SEMrush: semrush.com/partner/lex/ to get a free month of Guru - Pessimists Archive: pessimists.co/ - Eight Sleep: eightsleep.com/lex and use code LEX to get $200 off - BetterHelp: betterhelp.com/lex to get 10% off EPISODE LINKS: Manolis Website: web.mit.edu/manoli/ Manolis Twitter: twitter.com/manoliskellis Manolis YouTube: youtube.com/channel/UCkKlJ5LHrE3C7fgbnPA5DGA Manolis Wikipedia: en.wikipedia.org/wiki/Manolis_Kellis PODCAST INFO: Podcast website: lexfridman.com/podcast Apple Podcasts: apple.co/2lwqZIr Spotify: spoti.fi/2nEwCF8 RSS: lexfridman.com/feed/podcast/ YouTube Full Episodes: youtube.com/lexfridman YouTube Clips: youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: patreon.com/lexfridman - Twitter: twitter.com/lexfridman - Instagram: instagram.com/lexfridman - LinkedIn: linkedin.com/in/lexfridman - Facebook: facebook.com/LexFridmanPage - Medium: medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. 00:00 - Introduction 08:05 - Molecular basis for human disease 32:04 - Deadliest diseases 37:47 - Genetic component of diseases 46:38 - Genetic understanding of disease 1:02:25 - Unified theory of human disease 1:08:26 - Genome circuitry 1:33:29 - CRISPR 1:45:06 - Mitochondria 1:53:10 - Future of biology research 2:22:46 - The genetic circuitry of disease